Senior Clinical and Research Trial Physician - Neurosciences

Closing date: 28 October 2026

Job summary
The Department of Neuroscience is part of the network services care group and is one of the largest in the country. It covers southeast London and Kent and encompasses almost all aspects of neurological/ neurosurgical clinical care.

The post-holder will actively support clinical trial recruitment and delivery across Research Delivery Unit (RDU) 1 - Neurosciences, acting as a sub-investigator on a range of trials from phase 1 first in human to phase 3 trials. The post-holder will lead on complex clinical trials (such as CAR-T cell therapy and Advanced Therapy) and they will work closely with multidisciplinary clinical teams, Principal Investigators, academic partners and research delivery staff to promote and enhance research activity within the RDU and department of Neurology.

The post-holder is expected to work in adherence to Good Clinical Practice (GCP), research governance and Trust policies and processes. Additionally, the post-holder is expected to work autonomously, keep meticulous records and possess excellent organisational skills.

In addition to research work, the clinical research fellow may have the opportunity to undertake outpatient clinics at the Parkinson's centre of excellence as well as general neurology clinics. There may be an opportunity to participate in the unit's Neurology teaching program.

Main duties of the job

• Support the timely delivery of clinical trials conducted within RDU 1 - Neurosciences to acceptable medical standards, in line with the requirements of sponsors, ICH GCP, and other appropriate guidelines and regulations.
• Provide medical assessment and cover for selected studies, working alongside the clinical research delivery team in RDU 1.
• Initiate definitive strategies to anticipate and expertly manage medical safety issues, including emergencies.
• Act as Sub-Investigator on designated research studies.
• Be responsible for specific study-related medical decisions as agreed with the Principal Investigator.
• Assess participant eligibility against protocol-specific inclusion and exclusion criteria and maintaining up to date screening lists.
• Obtain informed consent in adherence to ICH GCP from study participants.
• Perform clinical assessments, medical histories and physical examinations and prescribing study medication.
• Perform clinical procedures as appropriate to the assigned study (including, but not limited to, clinical examinations or testing, insertion of intravenous lines, assessment of adverse events and management of medical emergencies).
• Evaluate and manage acute, sub-acute and chronic adverse drug reactions and manage acute toxicological emergencies under the supervision of the consultants in charge.

Job responsibilities

• Participate in the design and conduct of clinical research projects.
• Present research findings at local, national and international meetings.
• Contribute to publications, abstracts and conference presentations.
• Support grant development and translational research activity where appropriate.
• Undertake audit and quality improvement projects.
• Contribute to teaching medical students, trainees and multidisciplinary research staff.
• Support training in clinical research and clinical procedures.
• Participate in departmental educational meetings and journal clubs.

Essential

• Medical degree (MBBS, MBChB or equivalent recognised qualification).
• Full GMC Registration with licence to practise.
• Have completed ST1 - ST2 level post registration experience or equivalent.
• Current Good Clinical Practice (GCP) certification.
• Experience managing acutely unwell patients.
• Experience working within multidisciplinary teams.
• Understanding of clinical trial methodology and research governance.
• Experience of audit, quality improvement or service evaluation.
• Excellent communication and interpersonal skills.
• Strong organisational and time-management skills.
• Ability to obtain informed consent.
• Understanding of patient safety and pharmacovigilance processes.
• Ability to work independently whilst recognising limitations and seeking senior support appropriately.
• Ability to interpret clinical investigations.

Desirable

• MRCP, MRCS, MRCPath or equivalent postgraduate qualification.
• Higher research degree (MSc, MRes, MD or PhD).
• Advanced Life Support (ALS) certification.
• Publications or presentations in peer-reviewed scientific settings.
• Experience of advanced therapies, cellular therapies, gene therapies or regenerative medicine.
• Previous involvement in clinical research studies including recruitment and eligibility assessment.
• Participation in investigator meetings, monitoring visits or regulatory inspections.
• Competency in neurological clinical procedures (such as lumbar punctures).
• Basic statistical analysis experience.
• Knowledge of MHRA ATIMP regulations.
• Understanding of translational and experimental medicine research.
• Experience with electronic data capture systems and research databases.

Salary: £67,325 to £67,998 a year per annum plus London Weighting Allowance
Contract: Fixed term, 12 months
Working pattern: Full-time
Location: King's College Hospital, Denmark Hill, London, SE5 9RS

Contact: Cecilia Hultin, Head of Research Workforce, cecilia.hultin1@nhs.net, 02032993684

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. Apply through our website.

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and requires a Disclosure and Barring Service check.