Talent.com
Peptone
Senior Scientist I, Medicinal ChemistryPeptone • Greater London, England, United Kingdom
Senior Scientist I, Medicinal Chemistry

Senior Scientist I, Medicinal Chemistry

Peptone • Greater London, England, United Kingdom
3 days ago
Job type
  • Full-time
Job description

About the role


Working with the existing members of the Chemistry Department and various UK and overseas Contract Research Organizations (CROs), the successful applicant will support medicinal chemistry projects and coordinate synthetic chemistry activities to ensure the delivery of high-quality small molecule development candidates within competitive timeframes, while safeguarding the Company’s intellectual property by advancing its patent estate. This is a remote, desk-based role and does not involve wet work. May include occasional F2F meetings in the London to Cambridge corridor.


Main responsibilities


  • Efficient support of management of remote teams of medicinal and synthetic chemists at CROs.
  • Integrate and analyse project biology and DMPK data to enable successful hit-to-lead and lead optimisation campaigns through rational molecular design.
  • Timely upload of project data to company database and recording in ELN.
  • Support patent filings with experimental write up and data checking.
  • Work collaboratively within the Company’s project teams, with colleagues in biology, biophysics and computational sciences and with external collaborators such that objectives are met in a timely manner.
  • Communicate effectively, interpret and summarize complex data for presentation to different audiences.
  • Prioritise work according to project goals and take responsibility for the timely delivery of objectives.
  • Keep up to date with state-of-the-art technologies and knowledge of developments in medicinal chemistry.


Essential Requirements:


  • Education (PhD or MSc) in organic chemistry or medicinal chemistry with a strong track record of delivery and a breadth/depth of experience in an industrial drug discovery environment
  • 3-5 years drug discovery experience
  • Good knowledge of synthetic and medicinal chemistry
  • Managing remote teams of medicinal and synthetic chemists at Contract Research Organisations
  • Solid understanding of biological signalling pathways, structure-based drug design and ADME optimisation in drug discovery
  • Experience in preclinical drug discovery processes including hit identification, hit-to-lead and lead optimisation, to the delivery of development candidates


Nice to have:


  • Proficient in analysing and interpreting data from biophysical assays
  • Familiarity with data visualisation software (e.g., StarDrop, Spotfire, Vortex, DataWarrior)
  • Experienced in many elements of preclinical drug discovery process from target selection and hit identification, through hit-to-lead and lead optimisation, to the delivery of development candidates across multiple programmes
  • Experience of assessing the patent landscape around a target
  • Eagerness to develop leadership skills
  • Understanding of cheminformatics and/or modelling software (e.g. PyMol, KNIME, Torx) and ability to use ML tools to predict assay endpoints
  • Strong publication record in peer-reviewed journals and a track record of presenting at scientific conferences


All applicants should be able to demonstrate the right to work in the UK


View Peptone's job applicant privacy policy here: https://peptone.io/privacy/job-applicants/

Create a job alert for this search

Senior Scientist I, Medicinal Chemistry • Greater London, England, United Kingdom

Similar jobs

Senior Applied Scientist

Thomson ReutersGreater London, England, GB
Full-time

This posting is for proactive recruitment purposes and may be used to fill current openings or future vacancies within our organization.Are you excited about working at the forefront of applied res... Show more

 • Promoted

Medical Director, Early Clinical Development

BioMarin Pharmaceutical Inc.Greater London, England, United Kingdom
Full-time

BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions.Guided by our purpose to develop medicines that make a profound impact on people’s lives, our glob... Show more

 • Promoted

Senior Laboratory Research Scientist - Instrument Development and Prototyping

The Francis Crick InstituteGreater London, England, GB
Full-time +1

Senior Laboratory Research Scientist - Hardware Instrument Development and Prototyping.Reporting to: Andrea Serio – Group Leader.Contract term: This is a full-time, fixed term (2-year) position on ... Show more

 • Promoted

Applied AI Lead & Senior ML Scientist — Innovate & Deploy

JPMorgan ChaseGreater London, England, United Kingdom
Full-time

Join the Applied Innovation of AI team, a premier machine learning group within the Chief Technology Office of JP Morgan Chase.We tackle crucial business priorities using innovative machine learnin... Show more

 • Promoted

Oncology Medical Director - Hybrid/Remote Leadership

Ellipses PharmaGreater London, England, United Kingdom
Remote
Full-time

Ellipses Pharma is hiring a Medical Director in Greater London to oversee clinical trial protocols and strategy for oncology drug development.This role requires a strong background in medical oncol... Show more

 • Promoted

Senior Insights Lead: Medical Devices & Diagnostics

Ipsos in the UKGreater London, England, GB
Full-time

Ipsos Healthcare is seeking a Senior Research Executive to deliver impactful insights across healthcare clients.You will design, execute and deliver qualitative and quantitative studies, transformi... Show more

 • Promoted

Senior ML Scientist: Bayesian Optimization & Causal Design

Valence LabsGreater London, England, United Kingdom
Full-time

We’re seeking an experienced Research Engineer to shape and lead the development of software and AI systems that will help in our mission of industrializing scientific discovery to radically improv... Show more

 • Promoted

Senior Scientist I - Metabolite Identification (AMS)

PharmaronHoddesdon, England, GB
Permanent

Senior Scientist I - Metabolite Identification (AMS).Pharmaron is a global contract research and manufacturing organization (CRO/CDMO) helping pharma and biotech companies bring new therapies to li... Show more

 • Promoted

Senior Optical Research Scientist

CoMindGreater London, England, GB
Full-time

At CoMind, we are developing a non-invasive neuromonitoring technology that will result in a new era of clinical brain monitoring.In joining us, you will be helping to create cutting-edge technolog... Show more

 • Promoted

Senior Scientific Director — Healthcare Communications

Media ContactsGreater London, England, GB
Full-time

A healthcare communications agency is seeking a Scientific Director to start immediately for three months.The role involves leading workshops with clients and ensuring the production of high-qualit... Show more

 • Promoted

Senior Scientist Mass Spec

Tech4Good RecruitmentGreater London, England, GB
Permanent

This pioneering HealthTech organisation is transforming biomarker discovery through advanced machine learning and mass spectrometry.Their work focuses on rare, cardiac and neurodegenerative disease... Show more

 • Promoted

Senior Medical Science Liaison EMEA

TERUMO BCT, INCGreater London, England, GB
Full-time

Senior Medical Science Liaison EMEA.Our ability to grow, develop new capabilities and serve even more patients around the world depends on associates like you, who are passionate about our mission.... Show more

 • Promoted

Senior Scientist

Genomics plcGreater London, England, GB
Full-time

The growth of Genomics is partnered with the personal growth of our people.We ensure that all employees have the tools, technologies, benefits, and support systems to develop and flourish.We offer ... Show more

 • Promoted

Senior Manager – Scientific Engagement & Programs

Cpl Life SciencesGreater London, England, GB
Temporary

Senior Manager – Scientific Engagement & Programs.Direct message the job poster from Cpl Life Sciences.Supporting Commercial professionals within the Life Sciences industry: Sales & Business Develo... Show more

 • Promoted

Senior Research Scientist (27614)

Ecm SelectionGreater London, England, GB
Full-time

This senior position has a three-year term with a leading research institution and has strong Data Science elements.As a PhD-qualified scientist with further research or commercial experience, you ... Show more

 • Promoted

Director, Computational Biology & Drug Discovery (ML)

Recursion PharmaceuticalsGreater London, England, United Kingdom
Full-time

You'll report through our data science organisation, an interdisciplinary group powered by machine learning and inference-based discovery of drug programs from first principles.Your team will initi... Show more

 • Promoted

Senior Life Sciences Strategy & Growth Leader

The Consultancy Group (London)Greater London, England, United Kingdom
Full-time

A global healthcare consulting firm is hiring a Principal to lead strategic advisory engagements in Life Sciences.The role involves client leadership, business development, and overseeing high-valu... Show more

 • Promoted

Senior Medical Director, Global Medical Affairs – Neurosciences (Migraine Lead)

IpsenGreater London, England, United Kingdom
Full-time

Are you ready to lead and innovate in a dynamic, patient-focused biopharmaceutical company? Ipsen is a growing global specialty-driven biopharmaceutical company focused on innovation and specialty ... Show more

 • Promoted

Senior Optical Research Scientist

CoMind Technologies Limited.Greater London, England, GB
Full-time

At CoMind, we are developing a non-invasive neuromonitoring technology that will result in a new era of clinical brain monitoring.In joining us, you will be helping to create cutting-edge technolog... Show more

 • Promoted

Director - Discovery & Preclinical Research

NorthreachGreater London, England, GB
Full-time

Director - Discovery & Preclinical Research.Join an innovative biopharma company developing ground‑breaking therapeutics for sexual and mental wellbeing.The lead compound, in Phase 1 clinical trial... Show more