Immunoassay Senior Scientist

At Insmed every moment and every patient counts and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases youll be part of a community that prioritizes the human experience celebrates curiosity and values every persons contributions to meaningful progress. That commitment has earned us recognition as Science magazines No. 1 Top Employer for five consecutive years certification as a Great Place to Work in the U.S. and a place on The Sunday Times Best Places to Work list in the UK.

For patients for each other and for the future of science were in. Are you

About the Role:

We are seeking a highly experienced industry-trained Senior Scientist specialising in immunoassay development to join our evolving drug discovery team at Insmed Cambridge. This is an exciting lab-based opportunity for an innovative and motivated assay scientist with deep expertise in novel immunoassay design supporting a wide range of projects in our portfolio.

Operating within our Drug Discovery Biology team and sitting within the Compound Profiling group you will be accountable for designing implementing and delivering robust immunoassay data to support screening cascades that enable the progression of small molecule and oligonucleotide therapeutics from early target feasibility and Hit Finding through to Candidate Nomination.

You will act as our core subject matter expert for immunoassays taking ownership of experimental design and data generation. Applying a rigorous industry-standard approach you will develop novel highly sensitive assays to deliver high-quality reproducible bioanalytical data that informs project progression. You will collaborate closely with interdisciplinary teams to translate new biological insights into life-changing therapeutics.

What Youll Do:

Implementation of Screening Cascades & Assay Development:

• Collaboratively design implement and interpret immunoassaydata as part ofscreening cascades to advance drug discovery programs.

• Perform hands-on developmentoptimisation validation and troubleshooting ofhighly sensitivesingleplexand multiplex immunoassay formats (e.g. ELISA HTRFAlphaLISA MSD Luminex) to assess target engagement pathway modulation and mechanism-of-action.

• Apply strong pharmacologicalexpertiseandearly-stage fit-for-purpose method validation principlestooptimiseassay performance parameters to generate robust decision-enabling pharmacodynamic and target engagement data.

• Generate high-quality data tocharacterisenovel small molecule and oligonucleotide therapeutics informing structure-activity relationships and compound progression criteria.

• Support early pharmacokineticpharmacodynamic and immunogenicity assessments to drive LeadOptimisationand candidateselection.

• As part of the Compound ProfilingTeammaintainthe flexibility to run broaderin vitrocompound profiling assays (e.g. standard biochemical or cellular screens) to support the teams overall screening cascades and workload.

• Oversee data generation conducted at external vendors/CROs via scientific monitoring critically appraising scientific quality data interpretation andtimelydelivery.

TeamDevelopment & Culture:

• Contribute to a high-performingCompoundProfiling team acting as the core subject matter expert for immunoassays anddrug discovery cascade target engagement and pharmacodynamic marker dataacross the earlyDiscovery portfolio.

• Provide broad hands-on support for general compound profiling activities to driveDMTAcycles partnering with Chemistry DMPK and project teams to ensure assays align with project milestones and accelerate informed compound progression.

• Support mentor and develop junior scientists in immunoassay techniques and troubleshooting (with the potential for formal line management responsibilities depending on experience) promoting professional growth knowledge-sharing and a collaborative laboratory culture.

Enhancement of Experimental and Technical Capabilities:

• Continuously enhance in-house experimental capabilities by proactivelyidentifying evaluating and adopting innovative solutions and emerging immunoassay technology platforms (e.g. automated liquid handling ultra-sensitive detection platforms) depending on project needs.

• Contribute to further strengthening our research infrastructure and technological platforms supporting assay scalability throughput and long-term project successes.

Literature and Research Appraisal:

• Perform in-depth reviews and critical appraisal of scientific literature and internal data to informanalyteselectionand assay strategy.

• Work closely withour Target Discovery and New Projectteams to evaluate novel targets assess biological tractability and design bespoke innovative immunoassay solutions that directly underpin drug discovery and screening cascades.

Data Presentation and Collaboration:

• Analyse interpret and present high-quality data packages and reports at Project and Biology meetings to support informed matrix-driven decision-making and advance project milestones.

• Integrate learnings from disease biology andin vivopharmacology teams into assaystrategy ensuringin vitrotoin vivoalignment to support PK/PD modelling and dose-response evaluation.

Laboratory Documentation and Safety Compliance:

• Follow develop review andmaintainSOPs for immunoassay protocols instrumentation and laboratory workflows ensuring compliance with health and safety regulations.

• Accurately record experimental data using electronic lab notebooks (ELNs) and use industry-standard data analysis and management software to support high-quality reproducible research.

Who You Are:

• Degree coupled with extensive immunoassay orearly-stagetarget engagement/pharmacodynamic assaydevelopment experience for smallmolecule (and ideally oligonucleotide) projects within a drug discovery environment; it is typical at this level that you would have at least5years relevant experience.

• Proven track record in designing developing executing troubleshooting and interpreting a broad range of highly sensitivesingleplexand multiplex immunoassays (e.g. ELISA HTRFAlphaLISA MSD Luminex)applying fit-for-purpose methodvalidation principlesto rigorously assess target engagement pathway modulation and pharmacodynamicanalytes.

• Demonstrated experience contributing to DMTA cycles and working in close partnership with Chemistry DMPK and broader multidisciplinary teams.

• Experience managing and collaborating with CROs including oversight of immunoassay data generationcascadebiomarker assay development and compoundlogistics/management workflows.

• Working knowledge of standard assay automation (e.g. liquid handling and plate-based workflows) data analysis tools (e.g. GraphPad Prism) ELNs and scientific databases to supportbioanalyteassay developmentand profilingis essential.

• Strong verbal and written communication skills with the ability to clearly convey complex scientific concepts to diverse audiences.

• Excellent analytical thinking and numericalproficiency.

• Up-to-date awareness of latest technological developments in immunoassay platforms biomarker detection and pharmacology.

• Candidates with practical or applied experience with ultra-sensitive platforms (e.g.Simoa) cellular profiling techniques (e.g. flow cytometry high-content imaging) or evaluating novel modalities such as oligonucleotides would be highly desirable.

• Experience with broaderin vitroassay development (e.g. standard biochemical cellular or biophysical techniques) is highly desirable reflecting the flexibility and willingness to support the teams general compound profiling workload when.

• Prior experience in mentoring and developing junior scientists is essential while formal line management experience isadvantageous.

This role will require you to work from our brand-newstate-of-the-artoffices and labs situated in Babraham Research Campus South Cambridge. Hybrid working is offered based on specific business needs and the role requirements.

Life at Insmed

Our research site in Cambridge UK is situated in brand new labs and offices at the Babraham Research Campusa leading hub for bioscience innovation and collaboration. Our team of biologists human geneticists bioinformaticians data scientists computational and synthetic chemists bring together a wide range of technologies and modalities to deliver powerful new ways of treating serious diseases.

At Insmed youll find a culture as human as our missionintentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day with support for how you work how you grow and how you show up for patients your team and yourself.

Our offerings include:

• Flexible work schedules with purposeful in-person collaboration

• Competitive retirement benefits global equity awards and participation in our Employee Stock Purchase Plan (ESPP)

• Career development through the Insmed Learning Institute external programs LinkedIn Learning and role-specific training

• AI-powered and on-demand learning tools including a digital assistant to help navigate internal resources

• Hybrid-friendly technology and IT support for seamless teamwork across locations and time zones

• Global recognition programs and Employee Resource Groups

• Eligibility for specific programs may vary and is subject to the terms and conditions of each plan

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex gender identity sexual orientation race color religion national origin disability age or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access equal opportunity and reasonable accommodation for individuals with disabilities in employment its services programs and activities. To request reasonable accommodation to participate in the job application or interview process please contact us by email at

and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.

Required Experience:

Senior IC

Employment Type : Full-Time
Experience: years
Vacancy: 1