Talent.com
University of Cambridge
Bioinformatician - Disease Gene Discovery - Inherited Mitochondrial DiseasesUniversity of Cambridge • Cambridge, England
Bioinformatician - Disease Gene Discovery - Inherited Mitochondrial Diseases

Bioinformatician - Disease Gene Discovery - Inherited Mitochondrial Diseases

University of Cambridge • Cambridge, England
16 days ago
Salary
£42,254.00 yearly
Job type
  • Full-time
Job description
Lab Websites * Horvath Group: https://www.horvathlab-cam.co.uk/ * MRC MBU Research groups: https://www.mrc-mbu.cam.ac.uk/research-groups * Cambridge Clinical Mitochondrial Research team: https://www-neurosciences.medschl.cam.ac.uk/mitocamb/ * MRC MCuCluster: https://nmgn.mrc.ukri.org/clusters/mitochondria/ The University of Cambridge wishes to appoint a talented postdoctoral research associate in bioinformatics and computational biology to join a team of clinical, laboratory and computational scientists in the research groups of Prof Patrick Chinnery, Prof Rita Horvath and Dr Jelle van den Ameele at the Department of Clinical Neurosciences and the MRC Mitochondrial Biology Unit. The post holder will lead an exciting project to discover new genetic causes for mitochondrial diseases using novel computational approaches including A.I. and Bayesian statistical methods applied to genome wide datasets in families with incurable inherited disorders. Mitochondrial disorders affect ~1/5000 people but the genetic cause remains unknown in ~1/3 of families. The aim of this project is to discover new disease genes in undiagnosed patients from whole genome long and short-read datasets, bulk and single-cell RNAseq data, proteomic and metabolomic data. The post-holder will play a pivotal role co‑ordinating and analysing new data as part of large genomics projects (100k genomes project, UK Biobank, NIHR Bioresource, International Centre for Genomics Medicine in Neuromuscular Diseases) and perform an integrated analysis incorporating systematic phenotype ontologies to discover and validate new disease genes, linked to down‑stream functional analyses. The findings will cast light on disease mechanisms, reveal new treatment targets and immediately impact patient care. This role provides a unique opportunity to gain access to patient cohorts and clinical data alongside leading genomic technologies in the Cambridge cluster, and to work closely with other bioinformaticians, laboratory and clinical scientists in the University, Wellcome Sanger Institute, and the EMBL‑European Bioinformatics Institute. We anticipate this work will lead to high‑profile publications based on our track‑record: Nature Str Mol Biol 2026 PMID: 41922875; Science 2025 PMID: 41066576; Nature Medicine 2024 PIMID 8745010; Nat Comm 2023 PMID: 36823193, Cell 2023 PMID: 36827974; Nature 2022 PMID: 36198798. Candidates are expected to be independent, highly motivated, and keen to work collaboratively with wet‑lab and computational biologists within and outside the research groups. In addition to their own research, there will be opportunities for training and career development, and supervision of junior researchers. The role will be located within the MRC Mitochondrial Biology Unit housed in the Wellcome Trust/MRC Building on the Cambridge Biomedical Campus, with state‑of‑the‑art facilities available to group members, including computational resources (i.e. access to HPC facilities, a Linux cluster and storage). The lab and the wider University of Cambridge are committed, in their pursuit of academic and research excellence, to a pro‑active and inclusive approach to equality, which supports and encourages all under‑represented groups, promotes an inclusive culture, and values diversity. Flexible working and working from home arrangements will be considered. The University particularly encourages women and candidates from Black, Asian and Minority Ethnic backgrounds to apply. Fixed‑term: The funds for this post are available for 24 months (2 years) in the first instance, with the possibility of extending beyond this. For informal inquiries, please contact Rita Horvath (rh732@cam.ac.uk). The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. J-18808-Ljbffr
Create a job alert for this search

Bioinformatician - Disease Gene Discovery - Inherited Mitochondrial Diseases • Cambridge, England

Similar jobs

Senior Health Informatics Scientist, Real-World Evidence

DigitalhealthnewsCambridge, England, GB
Full-time

AstraZeneca is seeking a Principal Health Informatics Scientist to contribute to real-world evidence generation and observational research.This role involves driving strategies for healthcare data ... Show more

 • Promoted

Senior DMPK Scientist - PK/PD, MetID & In Vivo Lead

Vernalis (R&D) LimitedCambridge, England, GB
Full-time

Vernalis (R&D) Limited is seeking a highly motivated Senior Scientist II / Associate Principal Scientist in DMPK to support small molecule discovery in our Cambridge labs.You will design in vitro A... Show more

 • Promoted

Bioinformatics Specialist

Novogene EuropeCambridge, England, GB
Full-time

Novogene is a leading global provider of genomic services and solutions.Leveraging the latest next-generation sequencing (NGS), bioinformatics expertise, and the largest sequencing capacity in the ... Show more

 • Promoted

Director, Life Sciences (Health and Life Sciences)

WSP in the UK & IrelandCambridge, England, United Kingdom
Full-time

What if you could do the kind of work the world needs? At WSP, you can access our global scale, contribute to landmark projects and connect with the brightest minds in your field to do the best wor... Show more

 • Promoted

Bioinformatics NGS Lab Manager – Lead & Optimize

Mandarin RecruitmentCambridge, England, GB
Full-time

Mandarin Recruitment is looking for a Lab Manager for their global bioinformatics company based in Cambridge.The ideal candidate will have a bachelor's degree in bioengineering or molecular biology... Show more

 • Promoted

Postdoc Researcher: EDCs & MASLD Liver In Vivo

Centro de Investigación Príncipe Felipe (CIPF)Cambridge, England, GB
Full-time

Centro de Investigación Príncipe Felipe (CIPF) seeks a postdoctoral researcher to investigate the effects of chemical endocrine disruptors (EDCs) on Metabolically Associated Fatty Liver Disease (MA... Show more

 • Promoted

Associate Director, Systems Medicine

AstraZenecaCambridge, England, GB
Full-time

Location: The Discovery Center (DISC), Cambridge Biomedical Campus, UK.Salary: Competitive Salary and Benefits!.Are you ready to turn mechanistic models into dose and schedule strategies that prote... Show more

 • Promoted

RNA Resources Bioinformatics Data Engineer - AI Pipelines

SebibcCambridge, England, GB
Full-time

Sebibc is seeking a Bioinformatics Data Engineer based in Cambridge to enhance Rfam and RNAcentral databases.You will manage data pipelines, collaborate with cross-functional teams, and contribute ... Show more

 • Promoted

Antibody Discovery: Computational Protein Scientist

Barrington JamesCambridge, England, GB
Full-time

Barrington James is seeking an accomplished Computational Protein Scientist to apply machine learning and computational approaches to therapeutic antibody discovery and engineering in Cambridge.Wor... Show more

 • Promoted

Bioinformatics Data Engineer (RNA Resources)

SebibcCambridge, England, GB
Full-time

Rfam and RNAcentral are key resources for RNA biology, serving tens of thousands of users every year and widely cited in the scientific literature.We are recruiting a Bioinformatics Data Engineer t... Show more

 • Promoted

Senior Medical Device Development Lead

SRGCambridgeshire and Peterborough, England, GB
Full-time

A leading medical devices company is looking for a Device Development Lead to guide the design and lifecycle management of medical devices.In this role, you will lead cross-functional teams from co... Show more

 • Promoted

Computational Protein Scientist

Barrington JamesCambridge, England, GB
Full-time

We are seeking an accomplished Computational Protein Scientist to apply machine learning and computational approaches to therapeutic antibody discovery and engineering.Working at the interface of d... Show more

 • Promoted

Postdoc in Bayesian machine learning, AstraZeneca, Cambridge, UK

The International Society for Bayesian AnalysisCambridge, England, GB
Temporary

Postdoc in Bayesian machine learning, AstraZeneca, Cambridge, UK.PREDICTING DRUG TOXICITY WITH BAYESIAN MACHINE LEARNING MODELS.We’re currently looking for talented scientists to join our innovativ... Show more

 • Promoted

Senior Scientist, Molecular Diagnostics — NGS & DoE

TOGL (Holdings) LimitedCambridge, England, GB
Full-time

The Origin Group Limited, based at Granta Park in Cambridge, seeks a Senior Scientist to drive molecular biology method development, optimization, and validation for cancer diagnostics.This hands-o... Show more

 • Promoted

Director, Life Sciences Property Advisory

WSP in the UK & IrelandCambridge, England, United Kingdom
Full-time

WSP is seeking an experienced Life Sciences Director to expand our life sciences real estate advisory across England, building on multidisciplinary capability and helping clients make robust, comme... Show more

 • Promoted

Head of Translational Drug Safety — Biologics & Peptides

AiLuxCambridge, England, United Kingdom
Full-time

AiLux is seeking a Senior Director of Drug Safety in Cambridge, UK, to lead and establish its nonclinical safety strategies across innovative drug development.This pivotal role will involve establi... Show more

 • Promoted

Senior Computational Biologist, Aging & Omics Research

Altos LabsCambridge, England, GB
Full-time

Altos Labs in Cambridge is looking for a Scientist / Senior Scientist in Computational Biology to contribute to innovative aging and rejuvenation research.The ideal candidate will design computatio... Show more

 • Promoted

Senior AI/ML Engineer — Life Sciences, Boston Onsite

TetraScienceCambridge, England, United Kingdom
Full-time

TetraScience in Cambridge, UK, is seeking an experienced AI/ML product leader to design, develop, train, and validate advanced AI/ML products for life sciences.You will work with commercial teams, ... Show more

 • Promoted

Senior Associate Device Engineer

SRGCambridge, England, GB
Full-time

An exciting opportunity has arisen for a.Senior Associate Device Engineer.Working within a multidisciplinary engineering and scientific team, you will provide technical support across device develo... Show more

 • Promoted

Senior or Principal Scientist – 3D Molecular Modelling

OptibriumCambridge, England, GB
Full-time

Senior or Principal Scientist – 3D Molecular Modelling.Founded in 2009 and headquartered in Cambridge, UK, Optibrium develops software and novel technologies to improve the efficiency and productiv... Show more