About the role
We are seeking a collaborative and self-motivated bioinformatician post-doctoral fellow to work on investigating epigenetic alterations linked to different environmental aerosol exposures. Our previous work identified air pollutants associated with lung cancer promotion; however, the potential health risks associated with other aerosol exposures have not yet been well studied.
Prof Nnenna Kanu leads the Genome Plasticity laboratory at the UCL Cancer Institute and is the Chief Scientific Officer of the Cancer Research UK Lung Cancer Centre of Excellence. The Kanu Lab is a multi-disciplinary group of passionate and determined individuals who will provide the successful candidate with a stimulating and conducive environment to participate and grow as a scientist. The research in the lab is conducted in close collaboration with local and international scientists and clinicians, especially across the TRACERx and PEACE consortia and the CRUK Lung Cancer Centre of Excellence including prof Charles Swanton and Dr Dimitrios Anastasiou. These collaborative environments will provide the successful candidate with opportunities to learn from a large network of talented professionals.
This project aims to analyse how immune cells respond to environmental aerosol exposures over time using WGS/RNA/ATAC/DNA methylation sequencing and the consequent metabolomic changes in immune and epithelial cells. The candidate will study how environmental aerosol exposures affects specific immune cells in mouse lung cancer models and analyse relevant published human data. Environmental aerosol exposures -associated changes in human blood will be compared to early cancer signs observed in mice. The project will leverage existing whole-genome sequencing (WGS) data from current and former smokers, using multi-region matched primary and metastatic tumours from the TRACERx lung cancer evolution study, to investigate potential universal mutational signatures shared between smoking and other environmental aerosol exposures.
The position will be available for 2 years in the first instance, with the possibility of extension depending on funding availability.
Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B, with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.
Applications should include a CV and a Cover Letter:In the Cover Letter please provide evidence of the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the 'Why you have applied for this role' field in the application form, which is limited in the number of characters it will allow.)
About you
The successful applicant should have a proven track record of publications, have previous experience with genomics data analysis, be fluent in at least one of the following programming languages: C++, Python or R, and will have strong skills in the field of genomics and desirably one or more of the following: tumour biology, ctDNA/ blood-based biomarkers, evolutionary biology, statistics and mathematics.
What we offer
As well as the exciting opportunities this role presents we also offer some great benefits some of which are below:
Please visit to find out more.
Research Fellow - Bioinformatics - Environmental Carcinogens and Tumour Evolution Scientist • London
TRACERx is supported by the excellent bioinformatics facilities already available in our Centre together with substantial investment in bioinformatics staff, data storage and computer processing po... Show more
The intent of the fellowship is to focus on high risk research: ambitious projects that may not produce results, but will have lasting impact if they work.We believe that publication in AI/ML has b... Show more
A techbio company is seeking a Bioinformatics Engineer to design and build production pipelines for spatial transcriptomics and proteomics.This position requires a PhD and experience in startup env... Show more
Research Fellowing Alternative Proteins and Future Food.Funded by the Bezos Earth Fund, the $30m Bezos Centre for Sustainable Protein will apply cutting‑edge Engineering Biology to accelerate the a... Show more
A leading research institution in Greater London seeks a post-doctoral researcher to investigate the evolution of the megadiverse plant genus Solanum.You will work with an international team on phy... Show more
A leading research institute in hearing health seeks early career researchers to establish independent research groups through sponsorship for prestigious external fellowships.Successful candidates... Show more
F30D; Long-Term Recruitment: Senior Scientist / Postdoctoral Researcher / Lecturer / Professor.We are recruiting outstanding PhDs in science and engineering to participate in collaborative projects... Show more
OpenAI’s Forward Deployed Engineering team partners with global pharma and biotech, CROs, and research institutions to deploy existing expertise across the R&D value chain to help customers design ... Show more
A leading AI research organization is offering a 4-month fellowship titled 'Anthropic Fellows Program'.This position involves full-time research with mentorship from seasoned scientists.Candidates ... Show more
The group studies lymphovascular diseases, specifically Primary Lymphoedema, which is clinically and genetically heterogeneous and is caused by defects in the lymphatic system that lead to swelling... Show more
A leading biomedical research institute in Greater London is seeking a Postdoctoral Fellow.This full-time position focuses on lung cancer research within a multidisciplinary team, utilizing experim... Show more
A leading biomedical research institute in London seeks a Postdoctoral Fellow to join the Znamenskiy lab.The role involves leading projects studying neuronal responses using advanced imaging techni... Show more
Research Fellow (UCL – Data Science / Biomedical Research).University College London (UCL).University College London (UCL) is seeking to appoint a Research Fellow to contribute to an advanced resea... Show more
A leading blood cancer charity in London is seeking a Bioinformatics Research Scientist to support innovative projects focusing on population genetics and donor registry work.Responsibilities inclu... Show more
Alignerr is looking for a Remote Environmental Science Expert to develop and solve advanced environmental science problems.The position offers an hourly pay of $75–$90, requiring collaboration with... Show more
This is a rare opportunity for an engineer to join an elite R&D team, where your going to be working on the intersection of software and hardware development, working to develop the technologie... Show more
Senior Electronics Design Engineer - Mixed Signal.Ensure all your application information is up to date and in order before applying for this opportunity.An exciting opportunity has arisen for a Se... Show more
Job Title: Scientist, Biochemistry (Protein Expression, Enzymology & Discovery).We’re now a handful of people concentrating on practical enzyme projects that have clear commercial outcome... Show more
St Elizabeths Centre Much Hadham, Hertfordshire.Salary / Day Rate: Negotiable (dependent on experience).Are you ready to play a key role in shaping how learning is delivered across a truly values-... Show more
A vacancy at Chelsea and Westminster Hospital NHS Foundation Trust for a Colorectal Surgery registrar level post, with clinical duties at Chelsea and Westminster Hospital and West Middlesex Univers... Show more
