Post Doctoral Research Associate

About the role

We are seeking a highly motivated Post-Doctoral Research Associate to work on a new BBSRC-funded project 'Molecular grammar of a cell-type specific alternative splicing regulator' as part of an interdisciplinary team based at the Department of Biochemistry, University of Cambridge (Professors Chris Smith and Dr Katherine Stott) and the College of Life Sciences, University of Leicester (Professors Ian Eperon, Cyril Dominguez and Andrew Hudson). The project builds upon the discovery by the Cambridge team of the RNA binding protein RBPMS as a regulator of smooth muscle cell specific splicing and the finding that recombinant RBPMS can confer cell specific splicing in vitro, and self-assemble into phase separated states. The project will investigate the molecular and biophysical basis of splicing regulation using an array of state of the art biophysical, structural, molecular and chemical biology techniques, including single molecule analyses of splicing complexes as pioneered by the Leicester team.

The post-holder will work within the group of Professor Ian Eperon (Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology) in close collaboration with Professor Andrew Hudson (School of Chemistry) and Dr C. Dominguez (MCB and LISCB).

The work will involve designing and building a TIRF microscope with annular excitation pathways, creating a user interface for the microscope, single molecule TIRF microscopy and analysis of RNA-protein interactions by techniques including FRET.

Length of advert - 2 weeks

About you

You will hold a high‑quality first degree and PhD in Biochemistry or a related subject (or near completion), with a strong track record of research activity demonstrated through publications and presentations in leading scientific forums. You will bring hands‑on experience in single‑molecule microscopy, skills in optics or photonics, and proven ability in developing software for imaging analysis, particularly using Python. Your ability to work independently while contributing to a collaborative research team will be essential, as will excellent communication skills and a commitment to continuous professional development. You will thrive in an environment that values curiosity, originality and teamwork, and you will be motivated by the opportunity to lead experimental innovation within a world‑class research programme. The University of Leicester is committed to equity, diversity and inclusion, and to fostering a research culture where diverse perspectives are welcomed and all staff can contribute meaningfully to our collective ambition to create positive impact