Role of long non-coding RNAs in Zika virus-induced neuropathogenesis

Applications are invited for a fully-funded 4-year PhD studentship based in the Department of Pathology at the University of Cambridge under the supervision of Dr Nerea Irigoyen starting October 2025.

Long non-coding RNAs (lncRNAs) account for approximately 30% of human genes, and 40% are specifically expressed in the brain. Recent ribosome profiling analysis have shown that many cytoplasmic lncRNAs contain unannotated small open reading frames that can be translated into functional (micro)proteins involved in neurodevelopment.

Zika virus can be vertically transmitted to the foetus during pregnancy, leading to impaired brain development. These neuropathological mechanisms, a combination of viral genetics and host responses, still need to be fully understood. In this project, we will characterise how the differential expression of lncRNAs during infection will play a role in neuropathogenesis.

Funding

• will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for four years from October 2025.
• The studentships are available to students who qualify for UK Home fees.

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees.

Fixed-term : The funds for this post are available for 4 years in the first instance.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.