Senior Scientist Protein Antibody Engineering

200 staff. Limitless Potential. One team Cancer Research Horizons.

Senior Scientist Protein & Antibody Engineering Under the leadership of Nick Tribble

Salary : per annum (dependent on experience) plus benefits (includes up to 12 pension contribution and income protection)

Reports to : Group Leader Antibody Discovery

Department : Research and Innovation

Contract : Permanent

Hours : Full time 35 hours per week (flexible working requests considered)

Location : Cori Building Granta Park Cambridge

Closing date : 27 April 2025 23 : 55 Th is vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found therefore we strongly recommend that you apply early to avoid disappointment. If you require more time to apply as part of a reasonable adjustment please contact as soon as possible.

Visa Sponsorship : Cancer Research UK is able to consider visa sponsorship for this vacancy. If this applies to you please ensure that this is clearly marked on your application.

Int erview date : W / C 12 May 2025

At Cancer Research UK we exist to beat cancer.

We currently have an exciting opportunity within our Drug Discovery team for an experienced Senior Scientist to expand and enhance our capabilities in therapeutic antibody discovery.

About CRUK Drug Discovery

As the worlds biggest medical research charity weve helped bring eleven new cancer to market. However there is still an urgent need to bring more effective treatments to patients faster.

We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We havebrought together Cancer Research UKs established drug discovery teams under one organisation and leadership team combining our unique pipeline of cancer biology expertise and access to CRUKs worldclass academic network cutting edge technology platforms and clinical expertise to 1 bring new treatments to patients faster and 2 tackle the biggest challenges in discovering cancer by seeking out more radical ideas and embracing risk in our bid to achieve success.

Based at sites in Cambridge the CRUK Scotland Institute in Glasgow the Francis Crick Institute in London and Newcastle University Cancer Research Horizons employs 200 staff from both industrial and academic backgrounds

This is a great opportunity for a Protein Scientist Protein Engineering Scientist or Antibody Engineering Scientist to expand their skill set across protein engineering antibody screening & characterisation and protein science in a flexible environment with support from highly experienced colleagues from our multidisciplinary antibody discovery team. You will also have the opportunity to contribute to key pipeline and technology development projects and to showcase them to the wider organisation. We work in an inclusive environment where we welcome creative thinking and new ideas we would welcome your input on implementation of new technologies and improvements to existing processes and infrastructure. Furthermore we actively encourage our colleagues to celebrate our science by attending conferences presenting posters giving talks at events and publishing papers.

What will I be doing

Youll apply a range of molecular biology techniques to enable protein expression and antibody drug discovery.

Troubleshooting & designing solutions to drive innovative challenging drug discovery at pace.

Taking a leading role in sourcing production design QC and assessment of antigens & reagents required for discovery cascade.

Working with experienced colleagues to drive design and optimisation of therapeutic antibodies.

Working with colleagues and collaborators to examine and evaluate potential drug targets and associated biological hypothesises.

Supporting the expression and purification of antibodies and antibody fragment (scFv Fab VHH IgG) from bacterial and mammalian expression hosts to enable antibody characterisation.

Maintain and operate state of the art laboratory equipment.

Potential to line management of junior staff

What skills will I need

Degree and / or PhD in relevant field

Experience relevant to preclinical antibody drug discovery

Understanding of biotherapeutic candidate discovery ideally antibodies and the overall development process for biotherapeutic .

Experience of purified affinity tagged proteins and / or antibodies using AKTAs and other automated purification platforms.

Understanding of the requirements of protein QC analysis including techniques such as SDSPAGE HPLC and Western blotting.

Knowledge of current molecular biology techniques relevant to the construction and mutagenesis of protein expression vectors.

Awareness and / or experience utilising benefits of AI / ML within the context of antibody

Demonstrated ability to proactive drive research success prioritise own work effectively multitask and adapt flexibly to changing priorities.

Strength in collaborative working and proven ability to interact and communicate effectively with diverse stakeholders including those in academia

Proven ability to clearly communicate scientific objectives and project results.

Experience of automated liquid handling to enable the highthroughput expression and purification of protein is highly desirable.

Knowledge of performing affinity measurements of proteinprotein interactions recombinant protein activity assays and / or running of high throughput cell based assays is highly desirable.

Experience of informatic analysis and implementing and improving data workflows highly desirable

What will I gain

Every one of our employees contributes to our progress and is supporting our work to beat cancer. We think thats impressive.

In return we make sure you are supported by a generous benefits package a wide range of career and personal development opportunities and highquality tools policies and processes to enable you to do your job well.

Our benefits package includes a substantial retirement plan a generous and flexible leave allowance discounts on anything from travel to technology gym membership and much more.

We dont forget people have lives outside of work too and so we actively encourage a flexible working culture.

Our work from funding cuttingedge research to developing public policy will change the world. Its exciting to be part of our team.

How do I apply

We operate an anonymised shortlisting process in our commitment to equality diversity and inclusion. CVs are required for all applications; but we wont be able to view them until we invite you for an interview. Instead we ask you to complete the work history section of the online application form for us to be able to assess you quickly fairly and objectively.

Theres a place for everyone at Cancer Research UK. Our vision is to create a charity where everyone feels like they belong benefits from and participates in the work we do. Were committed to creating an inclusive culture where everyone can be themselves and reach their full potential.

We actively encourage applications from people of all backgrounds and cultures in particular those from ethnic minority backgrounds who are currently underrepresented and believe that a diverse workforce will help us to beat cancer sooner.

If youre interested in applying and excited about working with us but are unsure if you have the right skills and experience wed still love to hear from you. We dont expect everyone to meet all of the criteria listed.

We want to see every candidate performing at their best throughout the job application process interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen by emailing us at .

Unfortunately we are unable to recruit anyone below the age of 18 so that we can protect young people from health & safety and safeguarding risks.

Required Experience :

Senior IC

Key Skills

Laboratory Experience,Mammalian Cell Culture,Biochemistry,Assays,Protein Purification,Research Experience,Next Generation Sequencing,Research & Development,cGMP,Cell Culture,Molecular Biology,Flow Cytometry

Employment Type : Full-Time

Experience : years

Vacancy : 1

Yearly Salary Salary : 41700 - 46500