Talent.com
This job offer is not available in your country.
Associate Director, R&D - Process Chemistry

Associate Director, R&D - Process Chemistry

Jazz PharmaceuticalsSittingbourne, England, United Kingdom
30+ days ago
Job type
  • Full-time
Job description

This role requires you to be onsite full time based at our site on Kent Science Park in Sittingbourne.

Brief Description :

The Associate Director, R&D – Process Chemistry heads the process research and development team within the Discovery and Medicinal Chemistry group at Kent Science Park, adopting a leadership and technical role and working together with other CMC functions to advance drug candidates from lead optimisation to GLP Tox.

Essential Functions

  • Lead a group of scientists and is accountable for the development activities in the Process Development Team.
  • Analyse and evaluate medicinal chemistry synthetic procedures to redesign and / or identify scalable processes covering supply of early development activities up to GLP Tox.
  • Plan, agree, resource, and execute the optimization of a synthetic route, identifying clear deliverables and milestones in accordance with the overall molecule project plan.
  • Identify intellectual property generation opportunities and drive innovation within the team.
  • Present regularly project updates to the department and CMC teams with a focus on prioritization and delivery.
  • Act as the Drug Substance Lead and SME, working closely with other early CMC functions including analytical, preformulation, biopharmaceutics, Medicinal Chemistry, and toxicology.
  • Promote a purpose-driven team environment, with a focus on safety within the department.
  • Identify procedural and technical gaps within the department and drive implementation of optimized procedures.

Required Knowledge, Skills, and Abilities

  • Relevant pharmaceutical industry experience within a Discovery / Early Development setting with a broad understanding of early drug development and drug candidate nomination criteria.
  • Good understanding of key attributes that make a potential drug suitable for IND-enabling / clinical development.
  • Ability to survey scientific literature broadly beyond own discipline.
  • Excellent management skills, including planning and resource allocation.
  • Excellent verbal and written communication skills, including effective communication with external partners.
  • Strong IT skills and ability to use key software packages for data production, presentation, and analysis.
  • Demonstrated ability to lead projects from inception to completion, coordinating efforts within budget, timelines, and regulatory requirements.
  • Partner with Pharmaceutical Development on API development approaches to mitigate risk as candidates progress.
  • Display attributes aligned with Jazz’s values, encouraging their development in others.

    • Required / Preferred Education and Licenses

  • MSc / PhD in a chemical or pharmaceutical subject, ideally with postgraduate qualification in chemical synthesis, drug substance development, or related discipline.
  • Knowledge of quality and regulatory standards within the Pharmaceutical Industry in early phases and experience applying those into drug development projects.
  • cGxP awareness and experience applying this within an R&D environment.
  • Ideally, experience with statistical procedures and software, particularly DoE and multivariate analysis.

    • J-18808-Ljbffr

    Create a job alert for this search

    Associate Director • Sittingbourne, England, United Kingdom