Scientist / Senior Scientist, Drug Discovery

Nucleome Therapeutics is utilizing breakthrough genomics technologies to develop first-in-class antibody therapeutics for inflammatory diseases. Their approach relies solely on human disease genetics and biology, enabling the revelation of molecular disease mechanisms and the selection of drug targets through human genetic variants in the non-coding genome that influence gene expression. The company's proprietary 3D genomics combines laboratory and machine learning technologies applicable to any set of disease-associated variants. Founded by leading gene regulation experts from the University of Oxford and backed by top-tier life science investors, Nucleome is at the forefront of genomics-driven drug discovery.

Overview of the role :

The drug discovery team seeks a talented Senior Scientist with expertise in antibody characterization and analysis using primary immune cells. This role supports the pipeline of drug targets emerging from Nucleome's proprietary platform. It involves designing, developing, and executing assays for antibody screening, evaluation, target validation, and mechanism of action studies to advance multiple early-stage asset programs. Collaboration with experienced scientists across cross-functional teams is essential, with responsibilities including study delivery and regular presentation of findings.

Key responsibilities :

• Support multiple asset programs by designing, optimizing, and executing assays to evaluate antibody functions in primary immune cells, utilizing principles of cellular pharmacology (including Fc formats, ADCC / P, Kd, SPR, binding kinetics, antagonism, and agonism).

Use cellular immunology knowledge to design mechanism of action studies, interpret results, and suggest next steps, ensuring timely data submission and analysis using appropriate software.

Experience :

Skills and behaviors :

Preferred experience :

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